Blar i forfatter "Smith, Godfrey L"

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    • Hypothermia and cardiac electrophysiology: a systematic review of clinical and experimental data 

      Dietrichs, Erik Sveberg; Tveita, Torkjel; Smith, Godfrey L (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-13)
      Moderate therapeutic hypothermia procedures are used in post-cardiac arrest care, while in surgical procedures, lower core temperatures are often utilized to provide cerebral protection. Involuntary reduction of core body temperature takes place in accidental hypothermia and ventricular arrhythmias are recognized as a principal cause for a high mortality rate in these patients. We assessed both ...

    • Is hypothermia more neuroprotective than avoiding fever after cardiac arrest? 

      Dietrichs, Erik Sveberg; Myles, Rachel; Smith, Godfrey L (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-27)
      Hypothermia was increasingly proposed as a neuroprotective therapy in the 1990s, culminating in the publication of two randomized trials in 2002, which showed beneficial effects of therapeutic hypothermia in comatose survivors of cardiac arrest.1,2 Therapeutic hypothermia was subsequently included in guidelines for the treatment of this patient group. However, doubt as to whether hypothermia provided ...

    • Moderate but not severe hypothermia causes pro-arrhythmic changes in cardiac electrophysiology 

      Dietrichs, Erik Sveberg; McGlynn, Karen; Allan, Andrew; Connolly, Adam; Bishop, Martin; Burton, Francis; Kettlewell, Sarah; Myles, Rachel; Tveita, Torkjel; Smith, Godfrey L (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-02-07)
      <i>Aims</i> - Treatment of arrhythmias evoked by hypothermia/rewarming remains challenging, and the underlying mechanisms are unclear. This <i>in vitro</i> experimental study assessed cardiac electrophysiology in isolated rabbit hearts at temperatures occurring in therapeutic and accidental hypothermia.<p><p> <i>Methods and results</i> - Detailed ECG, surface electrogram, and panoramic optical ...

    • A novel ECG-biomarker for cardiac arrest during hypothermia 

      Dietrichs, Erik Sveberg; Tveita, Torkjel; Myles, Rachel; Smith, Godfrey L (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-10)
      <i>Background</i> - Treatment of arrhythmias evoked by accidental or therapeutic hypothermia and rewarming remains challenging. We aim to find an ECG-biomarker that can predict ventricular arrhythmias at temperatures occurring in therapeutic and accidental hypothermia.<p><p> <i>Main body</i> - Evaluation of ECG-data from accidental and therapeutic hypothermia patients and experimental data on ECG ...

    • Prediction of Ventricular Arrhythmias by QRS/QTc - Ratio in Citalopram or Escitalopram Intoxication 

      Dietrichs, Erik Sveberg; Smith, Godfrey L (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-16)
      <b><p>Background:</b> The U.S. Food and Drug Administration (FDA) has stated that citalopram and escitalopram should not be used at daily doses above 40 mg/20 mg due to risk for development of fatal ventricular arrhythmias like torsade de pointes (TdP). Yet, supratherapeutic serum concentrations of citalopram are common and predicting patients at risk for TdP is of high clinical value. Accordingly, ...

    • Pro-arrhythmic effect of escitalopram and citalopram at serum concentrations commonly observed in older patients – a study based on a cohort of 19,742 patients 

      Faraj, Pari; Størset, Elisabet; Hole, Kristine; Smith, Godfrey L; Molden, Espen; Dietrichs, Erik Sveberg (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-26)
      Background - For a decade, patients have been advised against using high citalopram- and escitalopram-doses due to risk for ventricular arrhythmia and cardiac arrest. Still, these drugs are widely used to treat depression and anxiety especially in older patients. It is unclear why they are cardiotoxic and at what serum concentrations patients are at risk for arrhythmias. Thus, how many patients that ...

    • Proarrhythmic changes in human cardiomyocytes during hypothermia by milrinone and isoprenaline, but not levosimendan: an experimental in vitro study 

      Selli, Anders Lund; Ghasemi, Mohammadreza; Watters, Taylor; Burton, Francis; Smith, Godfrey L; Dietrichs, Erik Sveberg (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-25)
      Background Accidental hypothermia, recognized by core temperature below 35 °C, is a lethal condition with a mortality rate up to 25%. Hypothermia-induced cardiac dysfunction causing increased total peripheral resistance and reduced cardiac output contributes to the high mortality rate in this patient group. Recent studies, in vivo and in vitro, have suggested levosimendan, milrinone and isoprenaline ...

    • Resistance to ventricular fibrillation predicted by the QRS/QTc - ratio in an intact rat model of hypothermia/rewarming 

      Dietrichs, Erik Sveberg; Selli, Anders Lund; Kondratiev, Timofei; McGlynn, Karen; Smith, Godfrey L; Tveita, Torkjel (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-04)
      Accidental hypothermia is associated with increased risk for arrhythmias. QRS/QTc is proposed as an ECG-marker, where decreasing values predict hypothermia-induced ventricular arrhythmias. If reliable it should also predict nonappearance of arrhythmias, observed in species like rat that regularly tolerate prolonged hypothermia.<p> <p>A rat model designed for studying cardiovascular function during ...